A Novel Approach for Formulation of Itopride Hcl Mups Sustained Release Tablet

MUPS tablet was prepared to control the release of Itopride Hydrochloride over a prolong period of time as multi unit particulate system are familiar, proven, easy to formulate and economical. The sustained released pellets containing Itopride Hydrochloride were prepared using a Fluidized bed processor technique. Amount of Microcrystalline cellulose (Avicel pH102, Hypromellose 15 cps and Ethyl cellulose 50 cps were taken as the formulation variables for optimizing to keep round shape of pellets and percentage release of drug. The pellets were evaluated for Physical characterization, Assay, Sizing, Aspect ratio, density, SEM, In-vitro drug release and Binder’s concentration tends to very effective pellets shape and size. Percentage release of drug intended to very non-linear with polymer type and percentage of coating on the pellets. In present investigation attempts were made to prepare 8 batches of multi unit particular tablets of Itopride Hydrochloride by using different polymers namely ethyl cellulose 50 cps and HPMC E-6 cps. The prepared tablets were evaluated for weight variation, thickness, percentage drug content, content uniformity, hardness disintegration time, in vitro drug release.